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Coadministration of encorafenib with delicate CYP3A4 substrates may perhaps bring about elevated toxicity or lowered efficacy of those brokers.
fentanyl transdermal and diazepam equally increase sedation. Stay away from or Use Alternate Drug. Limit use to sufferers for whom alternative therapy choices are inadequate
Diazepam has actually been revealed to be able to substitute for the behavioral effects of barbiturates within a primate examine.[128]
lumefantrine will lessen the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
If you want to assistance or assistance related to drug use please visit assistance for folks affected by medicines.
Check for signs of urinary retention or lessened gastric motility if oliceridine is coadministered with anticholinergics.
Stay away from driving or hazardous exercise until eventually you know the way this medication will affect you. Dizziness or drowsiness could cause falls, mishaps, or significant accidents.
nifedipine will boost the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Avoid or substitute One more drug for these prescription drugs when attainable. Appraise for lack of therapeutic outcome if medication must be coadministered. Adjust dose Based on prescribing information and facts if wanted.
lemborexant, diazepam. click here Possibly will increase consequences of the other by sedation. Modify Therapy/Check Carefully. Dosage adjustment can be vital if lemborexant is coadministered with other CNS depressants due to the fact of probably additive consequences.
crofelemer boosts levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected from the intestine; unlikely to inhibit systemically since minimally absorbed.
ceritinib will raise the amount or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
griseofulvin will lower the level or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Diazepam can take in into plastics, so liquid preparations really should not be stored in plastic bottles or syringes, and many others. As a result, it may possibly leach in to the plastic luggage and tubing used for intravenous infusions.